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The reasons for a link between vitamin B 12 deficiency and depression are not clear but may involve a shortage in S-adenosylmethionine (SAM)

[PMC free article] [PubMed] [Google Scholar] 60.Kim C, Xuong NH, Taylor SS

We actually prefer SQ because its painless and has an established track record of effective B12 delivery, whereas IM can be painful and tends to put people off self-injecting